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Someone has a heart attack every 40 seconds in the United States, according to the Centers for Disease Control and Prevention (CDC). To avoid the possibility, you could take medication like aspirin, which are supposed to reduce your chances of living a cardiovascular event. But other drugs could increase The risk of a heart attack in some people. In fact, research shows that a commonly prescribed medication can increase your risk of having a heart attack up to 21%.

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Proton pump inhibitors can increase the risk of heart attack up to 21%.

A study published in the journal Plos a highlighted the link Between fluently prescribed antacid drugs and heart attacks.

Researchers from Houston Methodist and the University of Stanford have examined health documents for nearly 3 million patients in the United States and have determined that patients using proton pump inhibitors (PPI) have an increased risk of heart attack from 16 to 21% compared to people who do not use this medication.

This risk was widespread throughout the general population, not just older adults or people with history of acute coronary syndrome (AC), which risk more heart attack, researchers said.

This study was one of the first to show a clear risk of PPI for the general population, as previous research had health officials thinking that the risk was relegated to a small subset of patients with coronary disease and also used antiplatelet clopidogrel to prevent future heart attacks.

"Investigators originally assumed that it was due to a drug-drug interaction Between these compounds, and the FDA went so far as to publish a warning regarding their concomitant use ”, the main author of the study Nicholas Leeper , MD, professor of surgery at the Stanford University Medical Center, said in a statement. "It led us to use powerful" big data "approaches to try to determine whether PPI could actually be associated with the risk in" all arrivals ".

Likewise, a study in 2024 published in the European Heart Journal have found that the use of the PPI is associated with an increased risk of cardiac arrest outside the hospital in the general population.

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Researchers found no increased risk of heart attack from another antacid drug.

PPIs are mainly prescribed to those who suffer from a gastroesophageal reflux disease (GERD). According to Medline Plus, there are many types of PPI, some of which are Available over the counter (OTC), like Prilosec, Nexium, Prevacid and Zegerid.

However, alternative drugs used to treat GERD may not have the same risk of heart attack.

According to the Plos a The study, patients who used H2 blockers (such as Tagamet, Pepcid and Axide) as an alternative treatment for GERD had no increased risk of having a heart attack. Unfortunately, doctors tend to use PPIs as the first line of defense of drugs in RGCs.

"The two drugs work by blocking and decreasing the Gastric acid production , but PPIs are considered stronger and faster to reduce gastric acids, "said Healthline experts when comparing PPIs and H2 blockers.

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PPIs were also linked to dementia and migraines.

Proton pump inhibitors could present health risks in addition to heart attacks.

A recent study published in Alzheimer's and dementia found that among people diagnosed with dementia between 60 and 69 years, those who used PPI had a Risk of 36% higher Compared to non-users.

A distinct study published in Neurology concluded that people who used PPI for more than 4.4 cumulative years were at a Risk 33% higher to develop dementia than those who have not used medicines.

In addition, a new study published in the journal Clinical practice in neurology suggests that IPP users are 70% more likely to feel migraines than non-users.

"Our report raises concerns that these drugs - which are available over -the -counter and are among the drugs most commonly prescribed in the world - would not be as safe as we have supposed before," concluded Leeper.