The new ozempic competitor for weight loss can be better tolerated
Doctors say that Zepbound can be an alternative for those who cannot manage semaglutide injections.
Now that he is so largely prescribed out of AMM to help people drop books, Ozempic has become somewhat synonymous with drug . It is despite the fact that it is in fact approved that the treatment of type 2 diabetes (his sister medication, Wegovy, is that approved to treat obesity.) But while these two treatments, which are Made by Novo Nordisk, are the first to come to mind thanks to their typically dramatic results, there are other market options, including a new competitor developed by Eli Lilly. Read the rest to find out why experts say that Zepbound could be better tolerated than Ozempic.
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Zepbound has recently been approved for chronic weight management.
Last week, the Food and Drug Administration of the United States (FDA) approved Zepbound for Chronic weight management In adults with obesity and at least one condition related to weight. The active ingredient, the shooting, is the same active ingredient in the treatment of diabetes of Eli Lilly, Mounjaro .
However, unlike Ozempic and Wegovy, Eli Lilly's treatments target two hormones, glucogenic peptide 1 (GLP-1) and insulinotropic polypetide (GIP) dependent on glucose to reduce hunger and make patients feel longer. Novo Nordisk's options only target GLP-1.
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Treatment has given significant weight loss results.
After a little 2018 study de Zepbound, during which patients lost almost 13% Of their body weight after three months, additional studies were carried out with larger patient pools.
According to a November 8 Press release From Eli Lilly, researchers have included 2,539 adult patients with obesity or overweight, who also had a weight -related medical problem. Participants received an injection of 5 milligrams, 10 milligrams or 15 milligrams of Zepbounds, or a placebo, once a week for 72 weeks.
All the patients followed a follow -up and the exercise, but those who also take Zepbound have lost much more weight than those who received the placebo. Patients receiving injections of 15 mg (the highest dose) lost an average of 48 pounds, while those who receive the 5 mg dose (the lowest dose) lost an average of 34 pounds. One in three taking 15 milligrams of Zepbounds also lost more than 58 pounds, or 25% of their body weight.
But beyond these impressive results, Zepbound could be easier to manage for those who fought with Ozempic and Wegovy, according to experts.
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Zepbound sometimes has fewer side effects.
The two NOVO Nordisk treatments have already been criticized for potentially serious side effects, including a painful condition called gastreresis or stomach paralysis. In response to requests for patient reports, the company previously said Better life that it values patient safety and gastrointestinal events (GI) "are well-known side effects in the GLP-1 class".
Novo Nordisk has also noted that GLP-1 can cause delay in gastric emptying, and symptoms of this, as well as nausea and vomiting, are listed as side effects. AE0FCC31AE342FD3A1346EBB1F342FCB
Despite this, several patients showed up to say that they Ozempic interrupted and the use of Wegovy accordingly. However, they can now have another option with Zepbound.
As doctors said Prevention , patients under shooting have Less side effects that when they are under semaglutide drugs.
"Some people who do not tolerate Wegovy do much better on Mounjaro / Zepbound", " Steven Bat , MD, gastroenterologist and leading doctor at Batash Endoscopic Weight Loss Center, told The Outlet.
Taking Zepbound is not "without risk" in terms of side effects.
Similar to Ozempic and Wegovy, Zepbounde mainly causes side effects linked to GI, Michael Russo , MD, bariatric surgeon certified on the board of directors at the MemorialCare surgical weight loss center in Orange Coast Medical Center, told Prevention .
According to the FDA, patients can specifically feel "nausea, diarrhea, vomiting, constipation, abdominal discomfort (stomach) and pain, injection site reactions, fatigue, hypersensitivity (allergic) (usually fever and rash), burping, hair loss and reflux disease gastroesopher [GERD]. "
The agency also noted that in rats studies, Zepbound caused thyroid tumors C, but it is not clear if it would cause similar tumors in humans. For this reason, the treatment is not recommended for patients with history of certain conditions, including spinal cord cancer.
Finally, as Leana Wen , MD, emergency doctor and medical analyst for CNN, explained, doctors do not know what Long -term side effects Tirzepatid and semaglutide could be, because these are "relatively recent therapies".
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