The perfect time to start hormone therapy to reduce the risk of dementia
The data suggests that starting earlier can reduce the chances of women in Alzheimer's disease.
Neurological diseases are particularly disturbing as we age - but dementia is not inevitability. Although there are different lifestyle factors that can increase your chances, fortunately there are also things you can do to lower your Risk of dementia . According to a new study, such a tactic is hormone therapy, which is used to treat the symptoms of menopause. Although hormone therapy has been debated in terms of effects on women's health, new research suggests that it could be an effective strategy to prevent Alzheimer's disease, if you start at the right time. Read the rest to discover what researchers say they are the ideal window for this treatment.
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Investigators evaluated data with more than 50 previous studies.
A study published last month in Borders in aging neuroscience looked at the use of hormone therapy and its Reduction efficiency Alzheimer's disease, the most common form of dementia. Alzheimer's is much more widespread in women, who have twice the risk to develop the disease during their lifetime in relation to men.
Investigators carried out a meta -analysis - which means that they have examined data from other studies without collecting new information. They evaluated six clinical trials and 45 observation studies where women received hormone therapy in living in life Press release by Weill Cornell Medicine. In total, the researchers examined data of more than six million women.
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Women who started younger treatment had a lower risk of dementia.
When compared with Women who Didn't Receive Hormone Therapy, Researchers Found That Women who Started Tooid Estrogen-Only Hormones During Permenopause (The Transitional Stage That Lasts Roughly Four To Eight Years) or Early Menopause to Treat Symptoms Had A 32 Dementia development. Interestingly, for women who started taking estrogens over 10 years after menopause, there was no significant drop in the rate of dementia.
"There is a Opportunity window , "Author of the main study Lisa Mosconi , PHD, director of the Alzheimer's prevention program and Brain's Brain initiative at Weill Cornell Medicine in New York, told CNN. "The hormones work better for the brain when they are taken in their forties in the presence of menopause symptoms to support women through menopause disease."
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Estrogen treatment has given better results.
Investigators also examined combined hormone therapy, where women received estrogens and progestogen during perimenopause or early menopause. Although there was also a reduced risk here, the researchers found that it was not statistically significant.
It should be noted that estrogen alone are generally given to women after hysterectomy (elimination of a uterus). For women with an intact uterus, they generally receive combined therapy to reduce the risk of uterine cancer. According to the press release, study researchers believe that progesterone could "blunt the preventive effect of mid-life estrogen".
Doctors too does not recommend Start hormone therapy only because you think it will reduce your risk of dementia, as Stéphanie Faubion , director of women's health of Mayo Clinic and medical director of the Menopause Society, said Wall Street's journal . If you have symptoms like hot flashes or sleep problems, health professionals say that it is when you can consider treatment.
Estrogens have long been considered a factor in the risk of dementia of women.
The researchers specifically examined estrogens because previous studies have shown that this can have a protective effect on the brain of women, according to the release of Weill Cornell. Thus, the loss of this hormone during menopause could explain why many more women develop Alzheimer's disease compared to their male counterparts. AE0FCC31AE342FD3A1346EBB1F342FCB
However, it is difficult to say with certainty if estrogens protect against these conditions, because Alzheimer's disease generally occurs decades after women crossed menopause in the previous 1950s.
"It is not really possible to direct a clinical trial of therapy for estrogen for this period to seek a dementia prevention effect," Mosconi said in the press release. "We need more clinical trials evaluating the effects of quarantine hormone therapy on organic indicators of Alzheimer's disease, which we can now measure using brain imagery and liquids such as blood. ""
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