A new drug has reduced cholesterol by 70% in a recent study. Could that help you?
This could reduce the risk of a third party heart attack, according to experts.
High cholesterol increases your risk of a range of serious health problems, including two main causes of death in the country: heart attack and blow. Unfortunately, the problem is terribly under treated, according to the centers for Disease Control and Prevention (CDC). "Just over half of American adults (54.5%, or 47 million people) who could benefit from cholesterol medicine Currently take it, "they note.
The good news? Experts produce increasingly effective means of treating high cholesterol when used in parallel with key lifestyle interventions such as healthy diet, regular exercise and cessation of smoking. In fact, recent studies have shown that a new drug can help reduce cholesterol up to 70%. Read the rest to find out if this can suit you and to know why people with cancer can also one day benefit from this revolutionary treatment.
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PCSK9 inhibitors can help reduce cholesterol by 70%.
Introduced for the first time on the market in 2015, PCSK9 inhibitors offer an alternative to the most common cholesterol drugs, statins. Currently, there are two PCSK9 inhibitory drugs approved by the FDA - Alirocumab (Praluent) and Evolocumab (Repatha). Both are administered in hospitals or primary care establishments in the form of injections every three months and monitored using blood tests. This created an obstacle to their generalized use, despite their apparent effectiveness.
However, a study of November 2022 published in the journal Cell reports tested one Oral version of the drug Using animal models and found that it has managed to reduce cholesterol by 70%. With additional research, this could open doors to the more widespread use of treatment in the future.
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Here's how these drugs work.
"PCSK9" means proprotein Convertase Subtilisin / Kexin Type 9 - a type of protein formed on the surface of liver cells which affects the number of low density lipoprotein receptors (LDL). According to the Cleveland Clinic, they strive to reduce the serum cholesterol levels by protecting your LDL receptors.
"" PCSK9 inhibitors Prevent PCSK9 proteins from decomposing your LDL receptors. The result is that more of your LDL receptors work. These LDL active receivers can then more effectively reduce your LDL cholesterol, "said health organization, adding that this particular drug" can reduce the risk of a heart attack by almost a third. "
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They are most often prescribed if other drugs have not worked.
Statins remain the most prescribed cholesterol drugs on the market. "Doctors often prescribe statins for people with strong Reduce their total cholesterol And reduce their risk of heart attack or stroke, "said the Mayo clinic." Although the statins are very effective and most sure for the most part rarely cause liver damage. ""
PCSK9 inhibitors can offer an alternative to people who experience side effects on statins or those who produce an inadequate response to the drug. However, they are still generally considered to be a backup, used only once other options have been exhausted. "Most people who have high cholesterol do not need to take PCSK9 inhibitors. Usually suppliers try other drugs before recommending these drugs," notes Cleveland Clinic.
One day they can offer advantages to cancer patients.
In addition to reducing cholesterol and by extension lowering the heart attack and Risk of stroke —The PCSK9 inhibitors can also one day offer a surprising advantage to those who reach cancer. Indeed, as researchers point out, PCSK9 inhibition can improve the efficiency of immunotherapy against cancer. AE0FCC31AE342FD3A1346EBB1F342FCB
"PCSK9 targets not only LDL receptors for degradation, but it also meditates the degradation of CMH 1 on lymphocytes, which is used for the recognition of cancer cells," Stamler said in the press release. "Pcsk9 effectively prevents your lymphocytes from recognizing cancer cells. So, if you inhibit Pcsk9, you can stimulate body cancer surveillance. There can be an opportunity one day to apply these new drugs to this need," -he explains.
Talk to your doctor to find out if PCSK9 inhibitors can suit you.
Best Life offers the most recent information from high -level experts, new research and health agencies, but our content is not supposed to replace professional advice. Regarding the medication you take or any other health issue you have, always consult your health care provider directly.
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