Doctors discover the combo of GLP-1 drugs which oversee weight loss after menopause
Comb a weight loss drug and hormone therapy can be the key to losing weight.
Menopause can trigger the beginning of physical and emotional symptoms. Hot flashes, difficulty sleeping, aging skin, mood changes and even Increase in heart health risk are All the common (and boring and sometimes frightening) symptoms of this life transition. In addition, many menopausal women complain about weight gain. The tenacious belly fat obtained its nickname for a reason, but the researchers have found a new method of double treatment which proves considerably beneficial for menopausic weight loss.
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Researchers say that GLP-1 drugs alone will only help menopausic weight loss.
For menopausal women who find it difficult to lose weight, using shooting (sold under Mounjaro brand names, approved for the treatment of diabetes, and Zepbound, approved for weight loss) in conjunction with menopause hormone therapy could be the answer.
A new study revealed that this double -treatment method causes significantly higher weight loss in menopausal women, compared to the use of obesity drugs alone, according to A press release Cetail the research presented by the endocrine company during the annual ENDO 2025 conference.
"The information collected by this new study provides important information to develop more efficient and personalized weight management interventions to reduce the postmenopausic health risk of overweight and health complications related to obesity," said Maria Daniela Hurtado Andrade , PHD, assistant professor of medicine and consultant for the endocrinology division of Mayo Clinic.
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The health risks associated with menopausic weight gain:
During menopause, there is a sharp drop in estrogen and progesterone levels. This triggers the beginning of metabolic changes, including a decrease in muscle mass and muscle tone. When this happens, "fewer calories are burned [and] fat accumulates" in its wake, explains Uchicago medicine . Menopausal women "also accumulate more fat because our metabolism slows down, contributing to more weight [gain]".
This "vicious cycle" is also powered by deposits of adipose tissue, which increases when the production of hormones slows down. Adipous tissue deposits tend to accumulate "around the median section", creating what doctors call a "menopause belly".
Menopausal women who are overweight or obese run an increased risk of developing diabetes, heart disease, high blood pressure, brain vascular accidents and respiratory problems, according to Uchicago Medicine. In addition, weight gain can contribute to joint pain, in particular arthritis and hinder mobility.
In addition, obesity can put you more at risk of breast cancer.
At the top of endocrine society, experts Research presented This indicates that shooting can reduce "growth of breast cancer associated with obesity". In a mouse model, the shooting has reduced the volume of cancer tumors, which, the scientists, "was significantly correlated with body weight, total adipose mass and the amount of fat stored in the liver".
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The combination of shooting and hormone therapy is better for menopausic weight loss.
The study concerned 120 menopausal women; 80 participants Only shooting used To help weight loss, and 40 participants used a combination shot and hormone therapy of menopause. Researchers have monitored their weight loss progress over a median duration of 18 months. They concluded that double treatment leads to a "percentage of total higher total body weight" in obese or overweight menopausal women.
The results were as follows:
- Three percent of additional women using the shooting plus the menopause hormone therapy have lost weight, compared to the users of shooting only (17% against 14%)
- Menopause hormone therapy is more effective than not using it at all
- 45% of menopause hormone therapy users saw at least 20% total body weight loss
"These data are the first to show the combined use of shooting hormone therapy and menopause considerably increases the effectiveness of treatment in menopausal women," said Regina Castaneda , MD, researcher at the Division of Endocrinology in Mayo Clinic.
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The point to take away:
As doctors have expressed it, postmenopausic weight gain "puts millions of women at risk of developing heart disease and other serious health problems". Although changes in food and exercise are intelligent action steps, a double -treatment method such as shooting the plus hormone therapy menopause can be significantly beneficial.
“This study highlights the urgent need for additional research to better understand how medication against obesity and menopause hormone therapy work together. Getting this knowledge could considerably improve the health and well-being of millions of menopausal women.
