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The question of someone who got vaccinated against Covid A is probable, "Has he worked? Although vaccines are very effective at preventing you from getting sick Sras-Cov-2, the shots like the virus itself does not affect everyone in the same way, which leaves a lot of 'between us ask. But if youhad side effects of the vaccine or notThe experts said that anyone who got his shot Covid or blows should know they are protected against the virus. However, according to new research, it turns out that those whomake a certain medicine May not have a fairly strong response from their Covid vaccine.

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A new study from the University of New York revealed that people who take methotrexate, a common anti-inflammatory drug for autoimmune disorders, tend to produce fewer antibodies after the vaccine, a key indicator of levels. immunity. (The vaccine works by triggering the production of antibodies that are then able to target, deactivate, and the virus label for the withdrawal of the body.) According to the study of May 25 which has been published in the medical reviewANNALS OF RHEUMATIC DISEASES, One in four people who take the methotrexate risea lower immune response At Vaccine Covid. The study specifically studied the people who received two doses ofPfizer vaccine which have also taken methotrexate to treat common self-immune disorders, including rheumatoid arthritis, psoriatic arthritis and psoriasis.

The researchers found that 90 percent of people not on the drug had strong antibody responses. On the other hand, only 62 percent of people taking methotrexate, which is sold like Rheumatrex, Trexall, Otrexup and Rasuvo-have been able to mount an adequate response. This could leave nearly 40 percent of people on still vulnerable drugs in Covid after their vaccine.

However, researchers are not yet sure of this means of protection.Rebecca Haberman, MD, co-author of the study, said in a statement that a lower antibody response does not necessarily mean that you are notProtected against the virus. "It is very important to clarify that patients should not be concerned about our study results than the majority of patients with immune system disorders respond well to MRNA vaccines," Haberman said. She noted that "it is also possible that methotrexate delays, rather than preventing, an adequate immune response against COVID-19. »

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Other researchers found that Covid vaccine antibody responses were upset by multiple self-immune disease drugs. Another study, published in May in the magazineAnnals of the Rheumatic Diseases, showed that in people with autoimmune disorders,Patients who take methotrexate And rituximab (rituxan) particularly respond to Covid vaccine, WebMD reports. Indeed, theseDrugs suppress the immune system so that the disorders, which causes the immune system of patients to hyperactive, are maintained under control.

In addition to this, a pre-impression of a joint study on Medrxiv in March found thatRegular infusions of Infliximab (Remicade) can make the first dose of the less efficient Pfizer vaccine. Remicade is a commonly used treatment to treat a variety of chronic inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, plate psoriasis, and ulcerative colitis. The study, which has not yet been examined by peers, found that many patients on Infiliximab ended up producing an adequate immune response after their second dose of vaccine, but some reaches sufficient immunity.

Researchers involved in the newest New York University study are saying vaccination strategies should be considered for those who have a decreased immune response. In a report,Jose U. Scher, MD, co-author of the study, potentially included stopping or modifying the dosage of methotrexate when the vaccine is administered or the administration of awakeup call. While Scher noted that a lower antibody "does not necessarily mean that the vaccine is not effective," it feels "alternative vaccination strategies should be studied. »

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