Can antidepressants really cure depression?
Depression has become one of the most spoken medical conditions that affect many of us. Depression is treated and addressed was a hot topic o
Depression has become one of the most spoken medical conditions that affect many of us. Depression is treated and addressed has been a hot topic of conversation recently. It has become a major health problem that dominates traditional media. The use of antidepressants is also very buzzing. It works, however?
A global subject
Are antidepressants safe and do they really work on you? It is something that has been widely discussed by doctors and researchers in recent years. This global debate on the subject of antidepressants was quite recent when the British author Johann Hari published his book,Lost connections: Discover the Real causes of depression - and unexpected solutions.
His book
Hari used antidepressants for about 13 years, something that started when it was only a teenager. Through its new book, it aims to unravel the answers to some of the issues that have been eating on the subject of antidepressants for years. He especially wants to know what caused his depression and why his antidepressants had not yet cured depression?
A controversy
Lost connectionsHas been launched as a fanfare of the recommendations of famous faces such as musicians Elton John and Brian Eno, Naomi Klein political activist and even Hillary Clinton. This led to an important question to be asked: "Does everything we know about depression is wrong?" There was a need for radical solutions. This soon caused a lot of controversy on the subject of depression.
The big debate
Lost connections has been assumed with a number of claims that antidepressants are mainly ineffective, that this uselessness has been elegantly covered by the pharmaceutical industry with all credits to regulatory systems, as well as physiological mechanisms that suggest most of the time. Depression that can not be arranged with proof.
Works for some
"Tell people, as I said by my doctor, that depression is caused by a problem in your brain, it is first false," explains Hari as he talks about the press on his understanding of the Depression. Nevertheless, there are so many unanswered questions about why antidepressants do not work on some people. So, is there an explanation on how it could be or why could it be?
Just a story?
As he has experienced depression and antidepressants first, he has a lot to say. "[A] Nd," Hari also said, "It's also really problematic because it cuts people to find the real causes of their depression and their anxiety. We have been telling this chemical history for 35 years and every year the depression and anxiety worsen. "
Invite changes
Claims like these have definitely alarmed health professionals and journalists. They made them more conscious and also concerned as ever after the book wording. There was also a thrust, in the community of mental health patients to stop using their medications without consulting an expert. It was really a stepping stone for people affected by depression to please.
In the words of Hari
In the meantime, others have become even more concerned about the impact of Hari's claims may have. His thoughts on antidepressants who "between 65 and 80% of people on antidepressants are depressed again in a year" has particularly caused the thoughts of these people involved in depression to think a little further.
Is it credible?
Even ifLost connections Aroused a lot of controversy has definitely struck a populist nerve, there were a lot of criticism about Hari's words. People were very quick to talk about the fact that it was only his second major work after the publication of a huge scandal of plagiarism with respect to his work in 2011. He had to stay away from the public for a while when that happened.
The Lancet Review
This ongoing discussion has begun to grow even more. It has been splashed in all social media and in several editorial columns because it is a problem that thousands of people treat each day. After waiting 6 long years, the systematic examination that weighs the usefulness of antidepressants entitledThe lancet finally been published.
Review of the exams
This was an exam that brought together all scientific data, those that have been published and unpublished for the staff at the University of Oxford to the United Kingdom could meet. This in-depth study was an analysis that was as careful so that it can hope to be the final verdict of highly heated antidepressure controversy.
The statement of Professor Carmin PARANTE
For example, the Pariant Carmine Professor who works as the Royal College of Psychiatrists spokesperson in the United Kingdom issued a statement regarding this review: "This meta-analysis finally puts the controversy on antidepressants, clearly showing that these drugs work in Lifting elevator and helping most people with depression. "
Modest but with an effect
"Especially", the punishing professor continues to say, "The document analyzes unpublished data held by pharmaceutical companies and shows that the financing of the studies of these companies does not influence the result, confirming, as well as the clinical usefulness of these Medications is not affected. By Spin Sponsored Pharma. "The exam concluded that even though the effects of antidepressants are short-lived and temporary, it has always had an impact on adults using it.
The financial burden
The effectiveness of drugs ranged from each other. Paroxetine (Paxil, BrisDelle, Pexeva), Agomelatin (Valdoxan), Escitalopram (Lexapro), Mirtazapine (Remeron) and Sertraline (Zoloft) had a very high response rate with a lower drop-out rate. Since depression is present on more than 350 million people, the need to clarify has become more crucial than ever. In America, the monetary burden of depression increased by about $ 210 billion a year.
How does antidepressants work?
The majority of antidepressants studied were the kind of medicine called selective serotonin rebupening inhibitors (SSRIS). The notion of operation of antidepressants is that they stimulate serotonin levels, even if it remains to be confirmed. Even levels of neurotransmitter serotonin are known to be high, although there has been no concrete evidence regarding this claim.
A myth on the pharmacy market
Serotonin is credited to maintain the functions of the mood balance, appetite and engine, cognitive and autonomous. Following the 1980s, low serotonin rates were blamed as excessive reasons for depression. Johann Hari and others have put words that go against this notion. In 2015, medical news were reported in an editorial printed in the BMJ by a SSRIS critic named David Heyly who debated that depression results with low levels of serotonin and that SRIS increase serotonin levels are a pharmaceutical. myth.
Need in depth search
Oxford researchers then made arguments that more updated research and best antidepressants are needed. They also stated that, since the effect of antidepressants can not be specified, it is necessary to choose a more specialized drug. Due to the amount of knowledge about antidepressants, a significant risk in the health of depressed people exists. Therefore, production for better and durable drugs must occur soon.
Risk of death?
The MNT made a recent discovery on antidepressants that may increase the risk of mortality. This research has suggested that these drugs increase the risk of premature death. This was a study by McMaster University in Ontario, Canada, which proposed a meta-analysis of 16 studies on a total number of approximately 3,75,000 participants, which saw a risk of premature death of 33% with antidepressants.
No clear test still
In addition, people who use antidepressants have been discovered to have a better chance of 14% of having a stroke, heart attack or other cardiovascular events. The meta-analysis failed to find the difference between the results of people who take sris and those using tricyclics, an earlier form of antidepressants. But researchers could not conclude whether antidepressants resulted in premature death or not. Marta Maslej The main author stated that "antidepressants disrupt the functioning of monoamines (important biochemies such as serotonin and dopamine), and these monoamines have important functions not only in the brain, but all the body."
An accepted point
"For example," it continued to say, "Serotonin affects growth, reproduction, digestion, immune function and many other processes, and is found in almost all major organs. The disturbance of the functioning of serotonin can therefore have different adverse effects, which can contribute to a risk of death in different different ways. "
All research has somewhat the same conclusion as if you use antidepressants, you should always consult your doctors when or if you feel that there are side effects.
